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Table 2 Stress conditions for fulvestrant

From: A novel UPLC-PDA isocratic method for the quantification fulvestrant in oil-based pre-filled syringe injection matrix formulations

Nature of stress Condition % Assay of stressed test Purity angle Purity threshold Purity flag
Unstressed NA 100.4 1.991 2.948 NO
Acid 2 N HCl@ RT, 18 h 104.0 2.255 3.206 NO
Base 2 N NaOH@ RT, for 18 h 100.5 1.809 2.658 NO
Peroxide 30% H2O2@ 70 °C, for 18 h 102.4 2.028 3.170 NO
Water 70 °C for 18 h 91.3 2.119 3.098 NO
Photolytic 1200 W/m2 200 million lux hours 101.6 0.134 5.329 NO
Thermal 70 °C for 18 h 97.0 2.060 2.985 NO
Humidity 90% RH for 7 days 102.8 0.143 5.336 NO
Metallic ion 0.05 M CuSo4 @ 10 min 99.0 0.475 8.427 NO