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Table 1 Box–Behnken design experimental runs

From: Design of experiment avenue for development and validation of RP-HPLC-PDA method for determination of apremilast in bulk and in in-house tablet formulation

Runs Factors Responses
Methanol composition (%) pH of aq. phase Flow rate (ml/min) Retention time Theoretical plates Tailing factor
1 60 3.5 0.8 7.56 2235 1
2 70 4 1.2 5.85 2466 1.35
3 70 3.5 1 5.32 2205 1
4 70 3.5 1 5.15 2257 1.04
5 70 3.5 1 5.15 2257 1.04
6 80 3 1 4.12 2136 0.85
7 80 4 1 4.13 2498 1.36
8 80 3.5 0.8 5.86 2245 1.03
9 60 3 1 7.45 2178 0.86
10 80 3.5 1.2 5.96 2305 1.05
11 70 3 0.8 5.12 2139 0.85
12 70 4 0.8 5.96 2496 1.41
13 60 4 1 7.55 2503 1.43
14 70 3.5 1 5.18 2265 1.05
15 70 3 1.2 6.23 2145 0.95
16 70 3.5 1 5.15 2245 1.05
17 60 3.5 1.2 6.98 2198 1.1