Table 3 Summary of forced degradation results
Stress condition | Duration | Assay of after forced degradation castanospermin (%w/w) | Assay of after forced degradation of celgosivir (%w/w) | Content of major degradant (%w/w) | Remarks |
|---|---|---|---|---|---|
Acid hydrolysis | 10 days | 100 | 100 | – | No degradation products formed for both |
Base hydrolysis | 0 h | .0 | 100 | 100 of CAS formed from CIL after 0 h | No degradation products formed for CAS |
Oxidation | 6 h | 79.2 | 90.0 | 20.8% n-oxide of CAS,10% of n-oxide CIL | n-oxides both sugars |
Thermal (105 °C) | 7 days | 100 | 100 | – | No degradation products formed for both |
UV light | 200 W/m2 | 100 | 100 | – | No degradation products formed for both |
Visible light | 1.2 million lux hours | 100 | 100 | – | No degradation products formed for both |