TY - JOUR AU - Chuong, Monica C. AU - Kelley, Charles J. AU - Muhammad, Yosra AU - Caputo, Thais Dias AU - Gomes, Jader M. AU - Oliveira, Denise AU - Peixoto, Andiara Cardoso AU - Pereira, Bruna Sanches AU - Rizg, Waleed AU - Vazquez, Carolina AU - Zacaron, Thiago Medeiros AU - Nguyen, Steven AU - Williams, David A. PY - 2018 DA - 2018/02/03 TI - Investigating effect of water of hydration on active pharmaceutical ingredients in a water-sensitive dosage form JO - Journal of Analytical Science and Technology SP - 7 VL - 9 IS - 1 AB - Preparation of mini buccal tablets incorporating either of the Alzheimer’s drugs, rivastigmine tartrate or donepezil hydrochloride, were developed for patients who have difficulty swallowing as a source of effervescence, by pairing the less commonly used malic acid with sodium bicarbonate in an experimentally determined (1:2) stochiometirc ratio. SN - 2093-3371 UR - https://doi.org/10.1186/s40543-018-0135-3 DO - 10.1186/s40543-018-0135-3 ID - Chuong2018 ER -