Table 1 Percentage of glucuronide formation after exposure to liver species for 20 h (DAD at 240 nm) and selectivity for forming the glucuronide 3 sorted by increasing selectivity

Rabbit

30.5%

6.7%

0.2

Mice

6.0%

4.9%

0.8

Dog

2.9%

2.8%

1

Chicken

4.4%

9.6%

2

Mini pig (miniature pig)

1.4%

6.4%

5

Horse

<0.1%

0.7%

8 ^a

Foal

<0.1%

1.4%

8 ^a

Porcine

1.6%

12.7%

8

Bovine

1.8%

24.0%

10

Rat

1.4%

26.9%

20

Sheep

0.4%

17.2%

45

Cynomolgus monkey

0.2%

13.4%

55

Guinea pig

0.2%

21.5%

101

Human

4.1%

77.1%

19