Scheme 1From: Human UDP-glucuronosyltransferase UGT1A4 forms tertiary N-glucuronides predominately with the energetically less favored tautomer of substituted 1H-indazole (benzpyrazole)Structures and atom numbering of drug candidate 1 and glucuronides 2 and 3. Both tautomers of 1 are shownBack to article page