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Table 1 RNA modification associated with disease and cellular dysfunction

From: Rapid and selective simultaneous quantitative analysis of modified nucleosides using multi-column liquid chromatography-tandem mass spectrometry

Modified nucleoside Related disease and cellular dysfunction Reference
m1A Leukemia, lymphoma, breast cancer, replication stress, abnormal conformation of tRNA (Anderson et al. 1998; Itoh et al. 1992; Cho et al. 2009)
I Hepatocellular carcinoma, replication stress (Jeng et al. 2009)
m2G Esophageal adenocarcinoma (Djukovic et al. 2010)
m7G Replication stress (Endres et al. 2015)
m2 2G Gastric cancer, intestinal cancer, lung cancer, esophageal adenocarcinoma, breast cancer, oxidative stress (Nakano et al. 1993; Djukovic et al. 2010; Cho et al. 2009; Chan et al. 2010)
m3C Alkylating stress (Chan et al. 2015)
m5C Oxidative stress, replication stress (Chan et al. 2010, 2012)
Cm Oxidative stress, replication stress (Chan et al. 2010)
s2C Interference with codon—anti-codon interaction (Agris 2015)
m5U Replication stress (Endres et al. 2015)
Ψ Gastric cancer, intestinal cancer, lung cancer, AIDS, leukemia, lymphoma (Nakano et al. 1993; Itoh et al. 1992)