Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride

Journal of Analytical Science and Technology

Table 4 Data for moisture loss studies for transdermal systems

Formulation code	Average initial patch weight* (mg)	Weight of the patch (mg)			Total moisture loss^a (mg)	% moisture loss^b,*	Rate of moisture loss^c,* (mg cm/cm² 24 h)
Formulation code	Average initial patch weight* (mg)	Day 1	Day 2	Day 3	Total moisture loss^a (mg)	% moisture loss^b,*	Rate of moisture loss^c,* (mg cm/cm² 24 h)
A1	206.13 ± 2.09	204.98	203.11	202.14	3.99 ± 0.042	1.97 ± 0.02	0.0170
A2	165.06 ± 1.60	164.76	163.18	161.74	3.32 ± 0.033	2.05 ± 0.023	0.0130
A3	202.48 ± 2.02	200.38	199.10	197.06	5.42 ± 0.051	2.75 ± 0.025	0.0193
A4	159.18 ± 1.39	157.83	154.91	153.86	5.32 ± 0.050	3.45 ± 0.031	0.0195
B1	237.82 ± 2.31	236.77	236.22	235.98	1.84 ± 0.012	0.77 ± 0.006	0.0075
B2	183.23 ± 1.79	181.38	180.82	179.84	3.39 ± 0.034	1.88 ± 0.014	0.0127
B3	178.44 ± 1.79	177.76	175.51	174.44	4.00 ± 0.043	2.29 ± 0.023	0.0155
B4	159.61 ± 1.49	158.17	156.43	155.11	4.50 ± 0.043	2.90 ± 0.027	0.0174
C1	205.20 ± 1.99	203.41	202.11	200.78	4.42 ± 0.044	2.20 ± 0.019	0.0161
C2	199.45 ± 1.89	196.24	194.99	192.87	6.58 ± 0.065	3.41 ± 0.028	0.0262
C3	243.91 ± 2.09	241.79	238.12	237.87	6.04 ± 0.060	2.53 ± 0.021	0.0250
C4	209.88 ± 1.99	205.14	203.76	202.54	7.34 ± 0.071	3.62 ± 0.031	0.0278

*Measurements taken in triplicate.
^aCalculated as initial weight − final weight of the patch
^bCalculated as (initial weight − final weight/final weight) × 100
^cCalculated as (weight lost (mg) × thickness of patch (mm))/surface area of patch (cm²)