Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride

Journal of Analytical Science and Technology

Table 3 Data for water vapor absorption studies for the prepared transdermal systems

Formulation code	Average initial wt. of patch* (mg)	Weight of patch (mg)			Total moisture gain^a,* (mg)	% moisture absorption^b,*	WVA rate (mg cm/cm² 24 h)^c,*
Formulation code	Average initial wt. of patch* (mg)	Day 1	Day 2	Day 3	Total moisture gain^a,* (mg)	% moisture absorption^b,*	WVA rate (mg cm/cm² 24 h)^c,*
A1	210.43 ± 2.10	210.67	210.89	211.17	0.74 ± 0.006	0.3516 ± 0.003	0.003161
A2	167.12 ± 1.12	167.24	167.37	167.44	0.32 ± 0.004	0.1914 ± 0.002	0.001259
A3	198.33 ± 1.72	198.65	198.91	199.23	0.9 ± 0.007	0.4537 ± 0.003	0.003217
A4	159.7 ± 1.23	159.81	160.12	160.36	0.66 ± 0.006	0.4132 ± 0.004	0.002426
B1	243.11 ± 2.17	243.67	243.81	244.1	0.99 ± 0.008	0.4072 ± 0.003	0.004051
B2	182.49 ± 1.81	182.72	182.87	183.12	0.63 ± 0.004	0.3452 ± 0.002	0.002364
B3	177.53 ± 1.59	177.63	177.89	178.37	0.84 ± 0.007	0.4731 ± 0.004	0.003261
B4	161.17 ± 1.51	161.35	161.49	162.61	1.44 ± 0.01	0.8934 ± 0.009	0.005591
C1	211.26 ± 2.01	211.31	211.56	211.64	0.38 ± 0.003	0.1798 ± 0.001	0.001386
C2	206.55 ± 2.09	206.64	206.82	207.08	0.53 ± 0.004	0.2565 ± 0.002	0.002115
C3	245.19 ± 2.13	245.57	245.91	246.24	1.05 ± 0.01	0.4282 ± 0.004	0.004349
C4	207.31 ± 2.10	207.76	207.87	208.09	0.78 ± 0.006	0.3762 ± 0.003	0.002955

*Measurements taken in triplicate
^aCalculated as Final weight − Initial weight of the patch
^bCalculated as (Final weight − Initial weight/Final weight) × 100
^cCalculated as (Weight gained (mg) × Thickness of patch (mm))/Surface area of patch (cm²)