Table 6 Results of forced degradation study of SIL drug using the developed stability-indicating HPLC method
SIL | ||||
|---|---|---|---|---|
Stress conditions | Heat temperature (°C) | Time (h) | Degradation (%) | RSD (%) |
Acidic (1.0 M HCl) | 80 | 1 | 11.98 | 0.32 |
Alkali (1.0 M NaOH) | 80 | 1 | 11.83 | 0.17 |
Oxidative degradation (5 % H2O2) | 80 | 1 | 50.85 | 1.45 |
Thermal degradation | 80 | 24 | 9.30 | 0.11 |