Accessible analytical methodology for assessing workplace contamination of antineoplastic drugs in limited-resource oncology health-care settings

Journal of Analytical Science and Technology

Table 3 Detection and quantification limits for ifosfamide, cyclophosphamide, and paclitaxel

	Limit of detection			Limit of quantification
Antineoplastic drug	Instrumental (ng/mL)^a	Wipe media (ng/cm²)^b	Concentrated wipe media (ng/cm²)^c	Instrumental (ng/mL)^a	Wipe media (ng/cm²)^b	Concentrated wipe media (ng/cm²)^c
Ifosfamide	10	0.2	0.02	32	0.8	0.08
Cyclophosphamide	41	1	0.1	124	3	0.3
Paclitaxel	13	0.3	0.03	39	1	0.1

^aCalculated as described in “Sensitivity” section
^bBased on the 400-cm² wipe area with extraction into 10 mL, no further concentration steps
^cBased on the 400-cm² wipe area with extraction into 10 mL, tenfold further concentration step