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Table 6 Stability data CA quality controls in human plasma

From: Bio-analytical chiral chromatography method for the enantioselective separation of carbinoxamine maleate in human plasma

Nominal con. (ng/mL)

Stability

Mean ± SD

Accuracy (%)

Precision (% CV)

(d)-form

(l)-form

(d)-form

(l)-form

(d)-form

(l)-form

300

0 h

317 ± 9.07

286 ± 8.34

106

95

2.86

2.91

12 h (bench-top)

323 ± 5.01

257 ± 2.76

108

86

1.55

1.07

24 h (in-injector)

326 ± 9.72

317 ± 5.2

109

106

2.98

1.64

Freeze-thaw

340 ± 12

296 ± 10

113

99

3.52

3.4

25 days at −80 °C

338 ± 1.47

318 ± 3.4

113

106

0.43

1.0

5000

0 h

4681 ± 54.3

4478 ± 28.9

93

90

1.16

0.64

12 h (bench-top)

4734 ± 47.4

5183 ± 38.5

95

104

1

0.74

24 h (in-injector)

4697 ± 35.1

5013 ± 60.7

94

100

0.74

1.21

Freeze-thaw

4737 ± 70.2

4826 ± 51.2

95

97

1.48

1.05

25 days at −80 °C

4705 ± 35.4

4478 ± 32.7

94

90

0.76

0.73