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Table 2 Screening of alcoholic modifiers

From: Bio-analytical chiral chromatography method for the enantioselective separation of carbinoxamine maleate in human plasma

Trail no.

Alcoholic modifiers

Alcoholic modifier (×) per 100 mL of mobile phase (mL)

Observations

1

Methanol

15

Poor resolution between the enantiomers, tailing of peaks observed

2

Ethanol

15

Enantiomers eluted very lately and the peak shape is broad.

3

Isopropanol

15

Enantiomers eluted early but not separated completely; no resolution between the peaks.

4

n-Butanol

15

No proper separation of enantiomers

5

Ethanol:isoproponol

7.5:.5

Enantiomers eluted early with good resolution and capacity factor.