Fig. 1

The human Plk family and the function and subcellular localization of Plk1 during the cell cycle. a A schematic diagram illustrating the structures of the human Plk family. Sequence identity (%) with Plk1 is shown. PB1 polo-box motif 1, PB2 polo-box motif 2, CPB cryptic polo box, PB3 polo-box motif 3. Numbers, amino acid residue numbers for each Plk. b A schematic diagram depicting the mitotic functions of Plk1 from G2/M transition to cytokinesis. c Subcellular localization of Plk1 in HeLa cells during the cell cycle. Kinetochore-localized Plk1 signals are colocalized with CREST antigens. Asterisks centrosomes. These images were originally published in Journal of Biological Chemistry. Seong YS, et al. A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells. 2002; 277(35):32282-93. © the American Society for Biochemistry and Molecular Biology