Stability indicating LC-MS/MS method for estimation of lovastatin in human plasma: application to a bioequivalence study

Journal of Analytical Science and Technology

Table 6 Stability of lovastatin in different storage conditions (n = 4)

Stability	Level	A	% CV	B	% CV	% change
Autosampler stability (~76.90 h, 10 °C)	LQC	0.358	7.00	0.359	1.57	−1.95
Autosampler stability (~76.90 h, 10 °C)	HQC	28.832	1.27	28.716	1.38	1.36
Bench top stability (~8.82 h, in ice-cold water bath)	LQC	0.358	1.46	0.359	2.60	2.64
Bench top stability (~8.82 h, in ice-cold water bath)	HQC	28.832	1.82	28.716	1.85	−0.57
Freeze-thaw stability (three freeze-thaw cycle)	LQC	0.358	1.46	0.359	2.75	2.05
Freeze-thaw stability (three freeze-thaw cycle)	HQC	28.832	1.82	28.716	1.85	0.36
Long-term stability (121 days, below −50 °C)	LQC	0.358	2.35	0.359	2.43	0.00
Long-term stability (121 days, below −50 °C)	HQC	28.832	0.63	28.716	0.96	3.94

A comparison sample concentration (ng/mL), B stability sample concentration (ng/mL), CV coefficient of variation