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Journal of Analytical Science and Technology

Table 4 Absolute matrix effect and process efficiency of lovastatin

From: Stability indicating LC-MS/MS method for estimation of lovastatin in human plasma: application to a bioequivalence study

QC sample

Aa (% CV)b

Bc (% CV)b

Cd (% CV)b

Absolute matrix effect (% AME)e

Process efficiency (%PE)f

LQC

35,950 (3.6)

35,521 (4.3)

27,239 (4.1)

98.81

75.77

MQC

1,415,891 (1.6)

1,406,632 (4.3)

1,130,372 (7.3)

99.35

79.83

HQC

2,716,145 (0.9)

2,641,614 (0.8)

2078,894 (1.8)

97.26

76.54

  1. aMean area response of six replicate samples prepared in reconstitution solution
  2. bCoefficient of variation
  3. cMean area response of six replicate samples prepared by spiking in extracted blank plasma sample
  4. dMean area response of six replicate samples prepared by spiking before extraction
  5. eB/A × 100
  6. fC/A × 100
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