Journal of Analytical Science and Technology

Table 1 Role of temperature on inter-conversion (n = 4)

From: Stability indicating LC-MS/MS method for estimation of lovastatin in human plasma: application to a bioequivalence study

A			B
QC sample	% accuracy		Protocol-A		Protocol-B
QC sample	Protocol-A	Protocol-B	A1	A2	A1	A2
LQC (0.359 ng/mL)	84.25 ± 1.86	61.37 ± 0.82	22,140	2015	16,470	2514
HQC (28.716 ng/mL)	86.07 ± 3.44	68.87 ± 3.40	1,704,693	68,417	1,413,647	82,503

Protocol-A: Samples were kept in ice-cold water bath for 6.0 h. Protocol-B: Samples were kept at room temperature for 6.0 h
A1 mean peak area observed at RT of LS (m/z: 422.1 → 285.4), A2 mean peak area observed at RT of LHA (m/z:423.3 → 303.7) both in positive ion mode

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