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Journal of Analytical Science and Technology

Table 2 Representative gene expression profiles in host cells as a result of virus infection or VLP stimulation

From: Systems biology from virus to humans

Host cells

Virus/VLPs

Gene expression profiles in host cells*

MDCKa

Influenza

TUBA2, CK-8, B-actin, keratin 10, ANXA1, KCIP-1

VEROb

Influenza

Keratin1, 8, 10, tubulin, TUBA, RBBP4, ITGA3, HSP27, Ndr1, ANXA4, PK, GAPDH, HSP105, ITGAV, dynein 1, HSP90, ITGA3, HSP 70

A549c

RSV

HRNR, HIST2H2BE, HIST1H2BC, H2AFX, DTX3L, IFI35, SYNE1, SUMO2, MYADM, PARP14, VIM, C21ORF70, TFAM, POLDIP3, DEK, EFHD2, KIAA1967, ENO1, ENY2

BEAS-2Bd

HBEC

RSV

ATP6V0D2, OTOA, SCNN1G, SMA5, CYP4F8, EPB41L4B, ELP2, PRKCE, HBP1, DUSP2, TUBB1, TRNT1, ELOVL5, PTPRG, MAP2K7, TSGA10, KRT12, SYN1, SIRPB1

MDDCe

HIV-VLP

Expression of genes involved in the morphological and functional changes characterizing the MDDCs activation and maturation: MEF2A, NFE2L2, DC-UbP, PGM3, DGKH, PTGS2, IL8, ARRB1, BTG3, SOSTM1, HLA-DOA - MHC class II, TADA3L, MTHFD2, PRKX, BAG3 KCNK10, member 10, PBEF1

PBMCf

HIV-VLP

Expression of genes involved in the morphological and functional changes characterizing the PBMCs activation and maturation: CTSL, IL3RA, SMOX, BCL2, G0S2, IER3, SERPINB2, LIMK2, IL6, IL8, PBFE1, PBX3, IL1-A,B, CCL3 (MIP 1α), CCL7, CCL18, CCL20, CXCL1, CXCL2, CXCL3, CXCL6, CXCL13, INHBA, ACTN1, AQP9, EMR1, SLC25A37, SLCO4A1, MAD, CCL4 (MIP1β)

RAW264.7g

HBc-VLP

HSP70, Eno1 protein chain A, peroxiredoxin 1, phosphoglycerate kinase, glutathione S-transferase A2, ferritin light chain 1, hypothetical protein, prohibitin, glyceraldehyde-3-phosphate dehydrogenase

  1. aMadin-Darby canine kidney (MDCK) cells that were infected with influenza virus (H1N1, A/PR/8/34) (Vester et al. 2010).
  2. bVero (kidney epithelial cells) cells that were infected with influenza virus (H1N1, A/PR/8/34) (Vester et al. 2010).
  3. cA549 (adenocarcinomic human alveolar basal epithelial cells) cells were infected with respiratory syncytial virus (Munday et al. 2010).
  4. dBEAS-2B4 (human bronchial epithelial cell line, subclone S6), human bronchial epithelial cells (HBEC) were infected with respiratory syncytial virus (Huang et al. 2008).
  5. eHuman monocyte-derived dendritic cells (MDDCs) were stimulated with HIV-1 (clade A) Pr55gag virus-like particles (HIV-VLPs) (Arico et al. 2005).
  6. fCD14+ human peripheral blood mononuclear cells (PBMCs) were stimulated with HIV-1 Pr55gag virus-like particles (HIV-VLPs) (Buonaguro et al. 2008).
  7. gRAW264.7 (mouse macrophage cell line) cells were stimulated with hepatitis B virus core protein virus-like particles (HBc-VLPs) (Yang et al. 2008).
  8. *Influenza: H1N1 (A/PR/8/34), HIV-VLp (HIV-1 Pr55gag virus), HBc-VLP (hepatitis B virus). Tubulin alpha (TUBA), protein kinase C inhibitor protein-1 (KCIP-1), nameretinoblastoma binding protein 4 (RBB4), serine/threonine kinase 38 (Ndr), MADS box transcription enhancer factor 2 (MEF2A), nuclear factor-like 2 (NFE2L2), dendritic cell-derived ubiquitin-like protein (DC-UbP), phosphoglucomutase 3 (PGM3), diacylglycerol kinase (DGKH), prostaglandin-endoperoxidase synthase 2 (PTGS2), interleukin 8 (IL-8), arrestin beta 1 (ARRB1), BTG familymember 3 (BTG3), sequestosome 1 (SOSTM1), MHC class II (HLA-DOA), butyrate-induced transcript (HSPC121), transcriptional adaptor 3 (TADA3L), Mst3 and SOK1-related kinase (MST4), UDP-Gal:betaGlcNAc bea 1.4-galactosyltransferase (B4GALT5), NAD-dependent methylenetetrahydrofolate dehydrogenase (MTHFD2), small glutamine-rich tetratricopeptide repeat (SGTB), protein kinase (PRKX), Nedd4 binding protein 1(X-linked N4BP1), pellino homologue 1(PELI1), sterol-C4-methyl oxidase-like (SC4MOL), BCL2-associated athanogene 3 (BAG3), potassium channel, subfamily K (KCNK10), pre-B-cell colony enhancing factor 1 (PBEF1), hornerin (HRNR), H2B type 2-E (HIST2H2BE), H2B type 1-C/E/F/G/ (HIST1H2BC), H2A (H2AFX), protein deltex-3-like (DTX3L), interferon-induced 35 kDa protein (IFI35), Nesprin-1 (SYNE1), small ubiquitin-related modifier 2 (SUMO2), myeloid-associated differentiation marker (MYADM), poly [ADP-ribose] polymerase 14 (PARP14), vimentin (VIM), uncharacterized protein C21orf70 (C21ORF70), transcription factor A, mitochondrial (TFAM), polymerase d-interacting protein 3 (POLDIP3), protein DEK (DEK), EF-hand domain-containing protein D2 (EFHD2), protein KIAA1967 (KIAA1967), a-enolase (ENO1), enhancer of yellow 2 transcriptionfactor homologue (ENY2), ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d isoform 2 (ATP6V0D2), otoancorin (OTOA), sodium channel non-voltage-gated 1 gamma (SCNN1G), cytochrome P450 family 4 subfamily F polypeptide 8 (CYP4F8), erythrocyte membrane protein band 4.1 like 4B (EPB41L4B), signal transducer and activator of transcription 3 interacting protein 1(ELP2), protein kinase C epsilon (PRKCE), HMG-box transcription factor 1 downregulated genes (HBP1), dual specificity phosphatase 2 (DUSP2), tubulin beta 1 (TUBB1), tRNA nucleotidyl transferase CCA-adding 1 (TRNT1), ELOVL family member 5 elongation of long chain fatty acids (ELOVL5), protein tyrosine phosphatase receptor type G (PTPRG), mitogen-activated protein kinase 7 (MAP2K7), testis specific 10 (TSGA10), keratin 12 ( KRT12), synapsin I (SYN1), signal-regulatory protein beta 1 (SIRPB1), glucuronidase, beta pseudogene (SMA5), EGF-like module containing, mucin-like, hormone receptor-like sequence 1(EMR1).
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