Selective spectrofluorimetric method for the determination of perindopril erbumine in bulk and tablets through derivatization with dansyl chloride

Journal of Analytical Science and Technology

Table 4 Precision and accuracy for determination of PDE in tablets

Tablets	Labeled amount of PDE	Average PDE found (mg/tablet) ± SD ^a (recovery %) ^b		t - and F test ^c
Tablets	Labeled amount of PDE	Proposed method	Reference method ^d	t - and F test ^c
Revosyl	4 mg	4.10 ± 0.036 (102.50)	4.06 ± 0.024 (101.50)	1.734, 2.207
	8 mg	8.34 ± 0.064 (104.25)	8.44 ± 0.040 (105.50)	2.464, 2.612
Neomeril	4 mg	3.86 ± 0.035 (96.50)	3.90 ± 0.026 (97.50)	1.604, 1.830
	8 mg	7.77 ± 0.075 (97.12)	7.87 ± 0.042 (98.37)	2.299, 3.196

^aAverage and standard deviation of five determinations for the proposed method and three determinations for the reference method.
^bRecoveries were calculated considering the labeled amount reported by the manufacturer.
^cThe tabulated t-value at 95% confidence limit for 4 degrees of freedom (n = 5) is 2.78 and the tabulated F value at 95% confidence limit for (4, 2) degrees of freedom for the proposed and reference methods, respectively, is 6.944.
^dHPLC (Raju and Rao 2011.