Bioanalytical method for quantification of Solifenacin in rat plasma by LC-MS/MS and its application to pharmacokinetic study

Journal of Analytical Science and Technology

Table 3 Stability of the samples

Stability	Spiked plasma concentration (ng/mL)	Concentration measured (ng/mL) (mean ± SD;n = 6)	(CV %) (n = 6)
Room temperature stability (25.0 h)	0.30	0.32	0.01	3.54
Room temperature stability (25.0 h)	75.00	77.30	1.28	1.66
Processed sample stability (61.5 h)	0.30	0.30	0.01	2.08
Processed sample stability (61.5 h)	75.00	78.83	0.67	0.84
Long term stability (45 days)	0.30	0.32	0.02	6.08
Long term stability (45 days)	75.00	71.93	2.90	4.03
Freeze-thaw stability (cycle 3, 48 h)	0.30	0.32	0.01	3.51
Freeze-thaw stability (cycle 3, 48 h)	75.00	77.65	0.59	0.76