Table 1 Biodistribution of 99m Tc-histamine in normal mice
From: Novel radiochemical and biological characterization of 99mTc-histamine as a model for brain imaging
Organs and body fluid | % I.D./organ and body fluid at different post-injection times | ||||
|---|---|---|---|---|---|
5 min | 15 min | 30 min | 120 min | 240 min | |
Liver | 8.11 ± 0.3 | 6.2 ± 0.1 | 5.2 ± 0.2 | 3.2 ± 0.1 | 1.3 ± 0.02 |
Urine | 5.10 ± 0.2 | 8.60 ± 0.11 | 18.1 ± 1.1 | 23.0 ± 2.3 | 31.5 ± 2.3 |
Kidneys | 10.5 ± 0.1 | 12.25 ± 0.3 | 16.8 ± 1.2 | 15.2 ± 0.3 | 6.30 ± 22 |
Blood | 28.4 ± 0.5 | 24.8 ± 0.9 | 6.1 ± 0.12 | 3.50 ± 0.1 | 1.2 ± 0.05 |
Heart | 1.3 ± 0.01 | 1.40 ± 0.02 | 1.6 ± 0.01 | 0.9 ± 0.03 | 0.70 ± 0.02 |
Lung | 30.5 ± 0.2 | 12.8 ± 0.3 | 11.30 ± 0.2 | 5.40 ± 0.10 | 3.25 ± 0.6 |
Intestine | 3.50 ± 0.1 | 2.80 ± 0.2 | 1.4 ± 0.02 | 1.2 ± 0.03 | 0.9 ± 0.02 |
Stomach | 1.6 ± 0.06 | 1.20 ± 0.02 | 2.2 ± 0.05 | 3.3 ± 0.13 | 3.70 ± 0.2 |
Spleen | 1.6 ± 0.03 | 4.52 ± 0.21 | 6.20 ± 0.2 | 5.3 ± 0.32 | 3.80 ± 0.16 |
Bone | 1.90 ± 0.1 | 1.6 ± 0.3 | 2.0 ± 0.11 | 1.80 ± 0.30 | 1.70 ± 0.13 |
Muscle | 1.8 ± 0.01 | 1.6 ± 0.03 | 1.5 ± 0.01 | 1.2 ± 0.06 | 1.10 ± 0.02 |
Brain | 7.1 ± 0.12 | 4.85 ± 0.6 | 1.4 ± 0.02 | 0.83 ± 0.06 | 0.62 ± 0.03 |
Thyroid | 1.3 ± 0.05 | 0.9 ± 0.02 | 0.7 ± 0.03 | 0.55 ± 0.01 | 0.32 ± 0.01 |
Brain/blood | 0.25 | 0.2 | 0.23 | 0.24 | 0.52 |