A selective and sensitive LC-MS/MS method for the simultaneous determination of twopotential genotoxic impurities in celecoxib

Journal of Analytical Science and Technology

Table 4 Robustness data of SHH and MAP PGIs at LOD and LOQ concentrations

Parameter	Actual	Low	High
Flow variation	0.7	0.63	0.77
Column oven temperature (°C)	40	38	42
SHH
%RSD at LOD	1.37	1.34	1.76
%RSD at LOQ	1.42	1.78	2.04
MAP
%RSD at LOD	0.68	1.42	0.74
%RSD at LOQ	2.14	1.63	1.91