Kinetic and Thermodynamic Spectrophotometric Technique to Estimate Gabapentin in Pharmaceutical Formulations using Ninhydrin

Siddiqui, Farhan Ahmed; Sher, Nawab; Shafi, Nighat; Shamshad, Hina; Zubair, Arif

doi:10.1186/2093-3371-4-17

Journal of Analytical Science and Technology

Table 5 Determination of gabapentin in pharmaceuticals formulations by proposed

From: Kinetic and Thermodynamic Spectrophotometric Technique to Estimate Gabapentin in Pharmaceutical Formulations using Ninhydrin

	Ini. Rate		Rate Constant		Fix Time		Reference method
	Gabaplus 100?mg cap (Platanium)
Taken	Found	%Rec	Found	%Rec	Found	%Rec	Found	%Rec
100	100.78	100.78	99.38	99.38	101.30	101.3	99.2	99.2
100	99.540	99.54	100.84	100.84	98.88	98.88	101.4	101.4
100	101.230	101.23	98.41	98.41	99.40	99.4	100.66	100.66
100	98.670	98.67	101.28	101.28	100.66	100.66	98.3	98.3
100	100.230	100.23	99.63	99.63	99.30	99.3	100.7	100.7
Mean	100.090	100.09	99.91	99.908	99.91	99.908	100.05	100.052
STD	1.014	1.01417	1.16	1.15662	1.02	1.023191	1.27	1.26512
RSD	1.013	1.013263	1.16	1.157685	1.024133	1.024133	1.264459	1.26446
T-Test	0.72		0.83		0.94
F-Test	1.26		1.39		1.05
	Gabin 200?mg cap (PharmEvo)
Taken	Found	%Rec	Found	%Rec	Found	%Rec	Found	%Rec
200	201.300	100.65	202.20	101.1	199.30	99.65	202.2	101.1
200	200.680	100.34	199.30	99.65	201.50	100.75	197.9	98.95
200	198.950	99.475	198.80	99.4	200.80	100.4	198.6	99.3
200	199.200	99.6	201.30	100.65	201.40	100.7	200.6	100.3
200	198.300	99.15	200.80	100.4	199.40	99.7	200.6	100.3
Mean	199.686	99.843	200.48	100.24	200.48	100.24	199.98	99.99
STD	1.254	0.627092	1.41	0.704805	1.07	0.533151	1.73	0.86342
RSD	0.628	0.628079	0.70	0.703117	0.531875	0.531875	0.86351	0.86351
T-Test	0.68		0.94		0.73
F-Test	1.25		1.48		1.17
	Neupentin 400?mg cap (Highnoon)
Taken	Found	%Rec	Found	%Rec	Found	%Rec	Found	%Rec
400	400.800	100.2	398.40	99.6	398.50	99.625	402.87	100.718
400	402.100	100.525	397.50	99.375	401.20	100.3	400.96	100.24
400	398.600	99.65	401.50	100.375	400.90	100.225	397.5	99.375
400	399.400	99.85	402.80	100.7	401.20	100.3	398.2	99.55
400	398.200	99.55	398.80	99.7	400.90	100.225	404.3	101.075
Mean	399.820	99.955	399.80	99.95	400.54	100.135	400.77	100.192
STD	1.616	0.404042	2.24	0.56097	1.15	0.287554	2.92	0.73106
RSD	0.404	0.404224	0.56	0.561251	0.287167	0.287167	0.729663	0.72967
T-Test	0.74		0.68		0.84
F-Test	1.39		1.47		1.14
	Gaba 100?mg cap (NabiQasim)
Taken	Found	%Rec	Found	%Rec	Found	%Rec	Found	%Rec
100	101.200	101.2	98.58	101.2	101.33	101.33	101.2	101.2
100	99.800	99.8	99.64	99.8	99.66	99.66	98.96	98.96
100	100.600	100.6	110.80	100.6	98.44	98.44	99.47	99.47
100	100.700	100.7	100.33	100.7	101.30	101.3	100.22	100.22
100	99.500	99.5	101.20	99.5	100.66	100.33	99.32	99.32
Mean	100.360	100.36	100.11	100.36	100.28	100.278	99.83	99.834
STD	0.695	0.694982	1.03	0.694982	1.23	1.230577	0.89	0.8919
RSD	0.692	0.692489	1.03	0.692489	1.227166	1.227166	0.892481	0.89248
T-Test	0.65		0.88		0.94
F-Test	1.37		1.62		1.08

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