Table 1 Identification of differentially abundant metabolites in LC–MS and GC–MS in Iran vs. China comparison

(3S,13Z,16Z)-3-amino-4-hydroxy-2-methyldocosa-13,16-dien-5-one

Lipids

6.77E−02

5.22E−08

Down

Cafestol

Terpenoids

1.68E−01

3.34E−07

Down

4-Hydroxyquinoline

Alkaloids

4.87E−01

6.38E−07

Down

N-carboxy-N-(2-oxo-2-phenylethyl)-L-alanine

Amino acids and derivatives

2.89E−01

1.22E−06

Down

4-[(2 s,3r,4r)-4-(3,4-dimethoxyphenyl)-4-hydroxy-2,3-dimethylbutyl]-2-methoxyphenol

Lignans and Coumarins

4.05E−01

1.53E−06

Down

3,4-Dihydro-4-(4'-hydroxyphenyl)-5,7-dihydroxycoumarin

Lignans and Coumarins

4.35E−01

1.97E−06

Down

4-hydroxy-3(3-methylbut-3-en-2-yl) benzaldehyde

Others

4.55E−01

2.22E−06

Down

linolenoylethanolamine

Lipids

3.87E−01

2.90E−06

Down

rhodomollein XI

Terpenoids

3.26E + 00

2.94E−06

Up

Tababiphenyl C

Others

3.18E + 00

3.11E−06

Down

UPLC-MS/MS

Tyr-Gly

Amino acids and derivatives

4.81E−01

3.19E−06

Down

Luteolin-6-C-(2''-glucuronyl)glucoside

Flavonoids

5.72E−02

4.50E−06

Down

Butylphthalide

Others

4.41E−01

5.41E−06

Down

β-Nicotinamide mononucleotide

Nucleotides and derivatives

2.13E−01

6.07E−06

Down

inumakiol G

Terpenoids

2.67E−01

6.81E−06

Down

14,15-Dehydrocrepenynic acid

Lipids

4.94E−01

7.92E−06

Down

DL-Glyceric Acid

Organic acids

3.75E−01

9.91E−06

Down

Uridine 5'-diphosphate

Nucleotides and derivatives

2.69E + 00

1.42E−05

Up

2-Methoxy-6-undecyl-1,4-benzoquinone

Quinones

2.86E−01

1.42E−05

Down

N-Benzoyl-(2R,3S)-3-phenylisoserine

Amino acids and derivatives

4.38E−01

1.48E−05

Down

Valproic Acid

Acid

3.73E−01

3.07E−06

Down

o-Xylene

Aromatics

3.81E−01

8.76E−05

Down

Acetic acid, 2-phenylethyl ester

Ester

2.28E−01

1.58E−04

Down

Pyrazine, 2-ethyl-3,5-dimethyl-

Heterocyclic compound

3.27E−01

1.83E−04

Down

trans-Linalool oxide (furanoid)

Heterocyclic compound

2.93E + 00

2.27E−04

Up

GC–MS

D-Limonene

Terpenoids

2.68E−01

2.91E−04

Down

1H-Pyrazole-1-carboximidamide, 3,5-dimethyl-

Heterocyclic compound

2.47E + 00

3.31E−04

Up

2-Acetyl-3,4,5,6-tetrahydropyridine

Heterocyclic compound

4.12E−01

3.54E−04

Down

cis-3-Hexenyl cis-3-hexenoate

Ester

3.55E−01

3.81E−04

Down

3-Hexene, 1-(1-ethoxyethoxy)-, (Z)-

Aldehyde

4.25E−01

4.84E−04

Down

2,4-Hexadienal, (E,E)-

Aldehyde

5.00E−01

6.02E−04

Down

Bicyclo[3.1.0]hexane, 4-methylene-1-(1-methylethyl)-

Terpenoids

7.97E−02

6.69E−04

Down

p-Cymene

Aromatics

3.23E−04

7.40E−04

Down

1H-Pyrazole

Heterocyclic compound

4.85E−01

7.42E−04

Down

2-Nonenenitrile

Nitrogen compounds

2.76E−01

7.71E−04

Down

Dodecane, 4,6-dimethyl-

Hydrocarbons

2.95E−01

7.94E−04

Down

Pyrazine, 3,5-diethyl-2-methyl-

Heterocyclic compound

4.13E−01

9.12E−04

Down

Benzene, 1-methoxy-4-propyl-

Aromatics

4.75E−01

9.30E−04

Down

Cyclohexanone

Ketone

4.54E−01

1.13E−03

Down

Acetic acid, heptyl ester

Ester

4.21E−01

1.13E−03

Down