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Journal of Analytical Science and Technology
Fig. 4 | Journal of Analytical Science and Technology

Fig. 4

From: Novel plasma-polymerized coating facilitates HeLa cell spheroid formation, exerting necroptosis via β-cyclodextrin-encapsulated resveratrol

Fig. 4

β-Cyclodextrin-encapsulated resveratrol (Res/CD) exhibits enhanced detrimental effects on HeLa cell spheroids compared with resveratrol (Res) alone. A HeLa cell spheroids were generated on the PECVD-coated plate for 5 days as described in Fig. 3 and then treated with 10 or 50 μM of Res or Res/CD for additional 3 days. The bar graphs represent the diameter (in the middle panel) and count of the spheroids (in the right panel). (mean ± SE, n = 8). p-values were calculated using the Student’s t-test. B HeLa cell spheroids were treated as described in panel A. Spheroids or detrimental spheroids were monitored daily under a microscope. Representative images are presented in the left panel, and the data were plotted as bar graphs (mean ± SE, n = 9). p-values were < 0.05 using two-way analysis of variance, followed by Tukey's test

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