Table 3 Matrix effect, recovery, and process efficiency of AZD5305 (mean ± SD, n = 5)
Nominal concentration (ng/mL) | Matrix effect (%) | Recovery (%) | Process efficiency (%) |
|---|---|---|---|
Mouse plasma | |||
AZD5305 | |||
3 | 96.5 ± 3.43 | 87.1 ± 9.59 | 84.0 ± 3.43 |
30 | 86.5 ± 0.906 | 99.5 ± 3.27 | 86.0 ± 0.906 |
900 | 87.1 ± 1.29 | 99.7 ± 1.79 | 86.8 ± 1.29 |
Olaparib (IS, 300 ng/mL) | 94.6 ± 5.15 | 98.3 ± 4.83 | 90.4 ± 4.19 |