Parameter | Intravenous | Oral |
---|
Tmax (h) | – | 0.875 ± 0.250 |
Cmax (ng/mL) | – | 11,400 ± 6,000 |
T1/2 (h) | 1.09 ± 0.07 | 7.86 ± 4.93 |
AUClast (ng·h/mL) | 25,600 ± 5,600 | 73,500 ± 24,300 |
AUCinf (ng·h/mL) | 25,700 ± 5,700 | 84,000 ± 16,400 |
CL (mL/h/kg) | 402 ± 85 | – |
Vss (mL/kg) | 648 ± 87 | – |
F (%)a | – | 65.4 |
- aCalculated by (AUCPO/DosePO)/(AUCIV/DoseIV) × 100
- AUC, Area under the plasma concentration–time curve; CL, total clearance; Cmax, maximum plasma concentration; F, bioavailability; SD, standard deviation; T1/2, terminal half-life; Tmax, time to reach Cmax; and Vss, steady-state volume of distribution