Fig. 2
From: Putting a bit into the polo-box domain of polo-like kinase 1
A schematic diagram illustrating hypothetical biochemical pathways between normal cells and Plk1-addicted cancer cells bearing an oncogenic RAS and/or a TP53 loss-of-function mutation. Reversal of Plk1 addiction (or gaining self-consciousness from Plk1 amnesia) may induce cancer cell–selective mitotic arrest and apoptotic cell death